Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation
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چکیده
منابع مشابه
Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation
The phosphatidylinositol-3-kinase/phosphatase and tensin homolog (PTEN)-mammalian target of rapamycin (mTOR) pathway regulates a variety of neuronal functions, including cell proliferation, survival, growth, and plasticity. Dysregulation of the pathway is implicated in the development of both genetic and acquired epilepsies. Indeed, several causal mutations have been identified in patients with...
متن کاملP3: Neuronal Death Following Posttraumatic Excitability and Seizure
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متن کاملNeuronal injury and death following focal mild brain injury: The role of network excitability and seizure
Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...
متن کاملp3: neuronal death following posttraumatic excitability and seizure
seizure may occur after mild traumatic brain injury (tbi), and the severity of tbi can be considered the most crucial factor for an increased risk of recurring seizures as well as for the development of posttraumatic epilepsy. however, the effect of seizures in epileptogenesis after mild tbi cannot yet be accurately confirmed. this study was designed to determine whether mild tbi increases seiz...
متن کامل[Cellular mechanisms regulating neuronal excitability: functional implications and in epilepsy].
INTRODUCTION AND METHOD The cellular mechanisms that regulate neuronal excitability and the propagation of electrical signals in the dendrites of pyramidal neurons are incompletely understood and of key functional and pathological importance. The capacity of dendrites to actively propagate action potentials is vital in processes related to memory and learning. The deregulation of dendritic exci...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2014
ISSN: 1662-5099
DOI: 10.3389/fnmol.2014.00018